[center:8e6f332c3e]Microinjection of NMDA receptor agents into the central nucleus of the amygdale alters water intake in rats.
[/center:8e6f332c3e]Abstract The central nucleus of the amygdala (CeA) is a forebrainstructures which are important in regulation of ingestive behavior andthere is direct and circumstantial evidence to indicate that somecircuits involved with feeding behavior include glutamatergic elements.The present study examined whether administration of NMA or MK801 inthe CeA altered water intake under deprivation. Animals were deprivedfor 24 h before tested for water intake. NMDA glutamatergic receptoragonist, NMA and its antagonist, MK801 were infused bilaterally, andwater intakes were measured for 1 h thereafter. The intra-CeA injectionof NMDA glutamatergic agonist NMA (0.25, 0.5 and 0.75 µg/rat) increasedWater intake (p<0.05). However, administration of NMDA glutamatergicantagonist, MK801 (0.25, 0.5 and 1 µg/rat) decreased Water intakesignificantly (p<0.05).